How to use ‘a role’ in a sentence

Are you looking for sentences with ‘a role’? See these examples of use.

… further show that a bouquet forms at the kar 3 SPB. Comparison of the expression of meiosis-specific Ndj 1 p-HA and Zip 1 p in haploid control and kar 3 time courses revealed that fewer cells enter the meiotic cycle in absence of Kar 3 p. Elevated frequencies of bouquets in kar 3 haploid meiosis suggest a role for Kar 3 p in regulation of telomere dynamics…

… but not after exposure to HBO. These results provide evidence in support of a role played by TNF-alpha in mediating HBO effects on different tissues and their immune responses…

… the absence of CD 31, while reduction of CD 31 reduced shear-sensitivity in some genes (e. g., eNOS), but not others (e. g., KLF- 2). Thus, CD 31 played a role in shear-sensitivity of some genes and of neutrophil recruitment, but not in…

… decreases allograft thromboxane production. Thus, the potent vasoconstrictor thromboxane A 2 may play a role in the impairment of renal function and renal blood flow during acute allograft rejection…

… 3. 5 h and reaches aerobic levels by 6 h. Cells lacking p 21, however, resume DNA synthesis more rapidly upon reoxygenation than wild-type cells, suggesting that this inhibitor may play a role in preventing premature reentry into the cell…

… differentiate prematurely before reaching their target. Our findings indicate a role for the SDF- 1 /CXCR 4 chemokine signaling system in DG morphogenesis. Finally, the DG is unusual as a site of adult neurogenesis. We find that both CXCR 4 and SDF- 1 are expressed in the adult DG, suggesting an ongoing role in DG morphogenesis…

… levels, chemotactic activity and CSF-white cell count was detected. Though the chemotactic activity of CSF from NB patients was only partially reduced by a human recombinant CXCL 11 antibody, these findings suggest that, among other chemotactic factors, CXCL 11 may play a role in the chemotaxis of mononuclear cells in NB…

… bound to siderophores and that it likely has a role also in siderophore-independent iron acquisition. We suggest that the FTT 0918 protein be designated Fe utilization protein A, FupA. Peer reviewed: YesNRC publication: Ye…

… nodes and spleens after peroral inoculation of mice. Involvement of the 100 -kb plasmid in infection of mesenteric lymph nodes and spleens suggests a role for the plasmid in the complex interaction of S. typhimurium with cells of the reticuloendothelial system…

… kinase activity, H- 7, H- 8, and dichlororibofuranosylbenzimidazole (DRB), inhibited elongation similarly to anti-TFIIH antibodies. These results strongly suggest a role for TFIIH in the stimulation of transcriptional elongation in vivo…

… task but not in the segregation tasks. We conclude that spatial arrangement plays a role in a texture segregation task requiring shape discrimination of the texture edge but not in a texture discrimination task in which it is sufficient to discriminate an iso-oriented region from a completely random region. status: publishe…

… activation (fMRI signal) in the bilateral mediofrontal cortex, anterior cingulate and left dorsolateral prefrontal cortex. The present findings allow the postulate that serotonergic medial forebrain and cingulum bundle pathways play a role in the activity of cortical structures involved in Stroop test processing. Key word…

… play a role in the aetiology of pathologies where glucohomeostatic mechanisms are disturbed, as is in type 2 diabetes mellitus. (c) 2005 Elsevier Inc. All rights reserved…

… prevented by pretreatment of the cells with Nacetylcysteine (an antioxidant) or H 7 (a PKC and PKA inhibitor) but not by HA 1004, a PKA inhibitor, suggesting a role for ROls and PKC in mediating c-jun gene expression. We also investigated potential…

… pretreatments was inhibited by calphostin C. Together, these findings suggest that PKC desensitizes MOR or has a role in the development of acute tolerance through MOR by inhibiting internalization mechanisms as a resensitization process.

… inducible nitric oxide synthase (iNOS) -positive residential macrophages in the external musculature of stomach and ileum, which significantly decreased after PEG-SOD or PEG-CAT treatment. The present results support a role for oxidative and nitrosative stress in the pathogenesis of septic ileus in mic…

… that intact Notch signaling was essential to this phenomenon. We also demonstrated a role for Notch/Jagged 1 signaling in the interaction between vascular pericytes and endothelial sprouts, the disruption of which limits the growth and…

… central effects of NO. The present results implicate neuronal NO generation in the pathogenesis of both direct and secondary excitotoxic neuronal injuries in vivo. As such they suggest that neuronal NO synthase inhibitors may be useful in the treatment of neurological diseases in which excitotoxic mechanisms play a role…

We investigated the role of metabotropic glutamate receptors (mGluRs), and related intracellular second messengers, in the development of morphine tolerance and dependence. The mGluRs are divided into three groups: group I mGluRs are positively coupled to phosphatidylinositol (PI) hydrolysis, while group II and III mGluRs are negatively coupled to cyclic adensoine- 3 $ sp prime$, 5 $ sp prime$-monophosphate (cAMP) production. Opioid receptors are also coupled to these same systems, and have been shown to elicit changes in these messenger systems during chronic treatment. We showed that chronic intracerebroventricular (i. c. v.) administration of selective group II and III mGluR antagonists concurrently with subcutaneous (s. c.) morphine significantly reduced the severity of precipitated withdrawal symptoms. Conversely, acute i. c. v. injection of a selective group II mGluR antagonist just prior to the precipitation of withdrawal significantly exacerbated the severity of abstinence symptoms. In addition, acute i. c. v. injection of a selective group II mGluR agonist just prior to the precipitation of withdrawal significantly reduced abstinence symptoms. From these results we hypothesized that chronic opioid treatment may induce a desensitization of group II mGluRs. We also demonstrated that chronic i. c. v. infusion of a selective group I mGluR antagonist concurrently with s. c. morphine significantly attenuated the precipitated withdrawal syndrome. In addition, we showed that chronic i. c. v. antagonism of $ delta$-opioid receptors with a highly selective antagonist also decreased the development of morphine dependence, as well as tolerance. Since both group I mGluRs and $ delta$-opioid receptors are positively coupled to PI hydrolysis, further evidence for a role of products of PI hydrolysis in the development of morphine dependence was obtained when we showed that selective chronic inhibition of protein kinase C (PKC) activation, as well as selective chronic…

… concentration of Compound 4. Our results provide evidence that SAP 4 – 6 play a role as regulators of the anti-Candida resistance to Compound 4. Compound 4 constitutes a suitable core to be further exploited for lead optimization to develop potent antimycotics…

Imitate experienced writers

Get inspired by millions of examples while writing.